Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have
been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …

Social interactions are a fundamental and adaptive component of the biology of numerous
species. Social recognition is critical for the structure and stability of the networks and …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

An emerging literature from epidemiologic, clinical, and preclinical investigations has
provided evidence that gestational exposure to infection contributes to the etiology of …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of
excitatory synapses. Small microdeletions and point mutations in SHANK3 have been …