The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The human solute carrier (SLC) superfamily of transporters is comprised of over 400
membrane-bound proteins, and plays essential roles in a multitude of physiological and …

Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global
epidemic. In order to achieve optimal glucose control, it is often necessary to rely on …

Accumulating evidence shows that metformin is an insulin-sensitizing antidiabetic drug
widely used in the treatment of type 2 diabetes mellitus (T2DM), which can exert favorable …

Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …

Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly
variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies …

Individual cells and epithelia control the chemical exchange with the surrounding
environment by the fine-tuned expression, localization, and function of an array of …

This review investigates the different biological effect of Metformin (MET) in different
conditions. MET is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus …