The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …

Improving protein stability is an important goal for basic research as well as for clinical and
industrial applications but no commonly accepted and widely used strategy for efficient …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

Abstract Knowledge of protein structure can be used to predict the phenotypic consequence
of a missense variant. Since structural coverage of the human proteome can be roughly …

A new version of FoldX, whose main new features allows running classic FoldX commands
on structures containing RNA molecules and includes a module that allows parametrization …

The recent severe acute respiratory syndrome, known as Coronavirus Disease 2019
(COVID-19) has spread so much rapidly and severely to induce World Health Organization …

Polyphenols are responsible for the major organoleptic characteristics of plant-derived foods
and beverages. Here, we investigated the binding of several polyphenols to bovine serum …

Highlights•Targeting critical sites for stability improvement.•Consensus/ancestral sequence
based protein stabilization.•Computational design of thermostability.•Loop grafting and …

Nemaline myopathy (NEM) is a common congenital myopathy. At the very severe end of the
NEM clinical spectrum are genetically unresolved cases of autosomal-recessive fetal …

Biocatalysis in organic solvents (OSs) has found various important applications, particularly
in organic synthesis and for the production of pharmaceuticals, flavors, and fragrances …