Acute myeloid leukemia (AML) is an invasive hematopoietic malignancy caused by
excessive proliferation of myeloblasts. Classical chemotherapies and cell transplantation …

Myeloid cells play a crucial dual role in cancer progression and response to therapy,
promoting tumor growth, enabling immune suppression, and contributing to metastatic …

As a new type of non-coding RNA, the role of circular RNA (circRNA) in various diseases
and tumors has received considerable attention. Studies have shown that circRNAs play an …

Overexpression and frequent mutations in FMS-like tyrosine kinase-3 (FLT3) are considered
risk factors for severe acute myeloid leukemia (AML). Hyperactive FLT3 induces premature …

FLT3 mutations are one of the most common genetic alterations in acute myeloid leukemia
(AML) and are identified in approximately one-third of newly diagnosed patients. Aberrant …

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules.
Four types of circRNAs have been reported in animal cells, and they have typical …

Fms-like tyrosine receptor kinase 3 (FLT3) proteolysis-targeting chimeras (PROTACs)
represent a promising approach to eliminate the resistance of FLT3 inhibitors. However, due …

Ligand modification by substituting chemical groups within the binding pocket is a popular
strategy for kinase drug development. In this study, a series of pteridin-7 (8 H)-one …

Acute myeloid leukemia (AML) with internal tandem duplication (ITD) mutations in the FLT3
tyrosine kinase tend to have a poor prognosis. FLT3‑ITD can promote the progress of AML …

Abstract Cluster of differentiation 99 (CD99) is a receptor that is significantly upregulated in
acute myeloid leukemia (AML). FMS-like tyrosine kinase 3 internal tandem duplication …