Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population
of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some …

Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic
stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be …

MLL is a target of chromosomal translocations in acute leukemias with poor prognosis. The
common MLL fusion partner AF9 (MLLT3) can directly bind to AF4, DOT1L, BCOR, and …

WNT proteins constitute a very conserved family of secreted glycoproteins that act as short-
range ligands for signaling with critical roles in hematopoiesis, embryonic development, and …

Overexpression of TRIM24 is observed in several human cancers and is correlated with an
increase in the progression and metastasis of tumors. In this study, we investigated the …

Targeting protein‐protein interactions (PPIs) with small‐molecule inhibitors has become a
hotbed of modern drug development. In this review, we describe a new class of PPI …

Meis1 is a transcription factor involved in numerous functions including development and
proliferation and has been previously shown to harness cell cycle progression. In this study …

The retinal determinant gene network (RDGN), originally discovered as a critical
determinator in Drosophila eye specification, has become an important regulatory network in …

The promoting roles of transcriptional factor six1 have been shown in various tumors, such
as breast cancer and colorectal Cancer. However, its roles in hepatocellular carcinoma …