Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

During drug discovery and prior to the first human dose of a novel candidate drug, the
pharmacokinetic (PK) behavior of the drug in humans is predicted from preclinical data. This …

This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …

Non-animal methods for toxicokinetics, such as in vitro hepatic metabolic clearance studies,
play an important role in chemical risk evaluations. To gain regulatory acceptance of such …

Modern society continues to pollute the environment with larger quantities of chemicals that
have also become more structurally and functionally diverse. Risk assessment of chemicals …

Predicting human pharmacokinetics (PK) such as clearance (CL) and volume of distribution
(Vd) is a critical component of drug discovery. These predictions are mainly performed by in …

The lack of adequate anti-leishmanial therapies has led to the continued suffering of millions
of people from developing nations. Moreover, optimism for a therapeutic intervention by …

As lead optimization efforts have successfully reduced metabolic liabilities due to
cytochrome P450 (CYP)-mediated metabolism, there has been an increase in the frequency …

Combination therapy drugs are considered a fundamental way to control malaria as it
mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently …

Background: DMPK data and knowledge are critical in maximising the probability of
developing successful drugs via the application of in silico, in vitro and in vivo approaches in …