Transition-metal-catalyzed C–H bond activation for the formation of C–C bonds in complex molecules

JH Docherty, TM Lister, G Mcarthur, MT Findlay… - Chemical …, 2023 - ACS Publications
Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …

Fluorescent probe strategy for live cell distinction

X Liu, YT Chang - Chemical Society Reviews, 2022 - pubs.rsc.org
Live cell discrimination is the first and essential step to understand complex biosystems.
Conventional cell discrimination involving various antibodies relies on selective surface …

Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies

M Bertolini, MS Wong, L Mendive-Tapia… - Chemical Society …, 2023 - pubs.rsc.org
T cells are an essential part of the immune system with crucial roles in adaptive response
and the maintenance of tissue homeostasis. Depending on their microenvironment, T cells …

Late‐stage C− H Functionalization of Tryptophan‐Containing Peptides with Thianthrenium Salts: Conjugation and Ligation

N Kaplaneris, A Puet, F Kallert… - Angewandte Chemie …, 2023 - Wiley Online Library
Bioorthogonal late‐stage diversification of structurally complex peptides bears enormous
potential for drug discovery and molecular imaging, among other applications. Herein, we …

Enzyme‐activatable near‐infrared hemicyanines as modular scaffolds for in vivo photodynamic therapy

Z Cheng, S Benson, L Mendive‐Tapia… - Angewandte …, 2024 - Wiley Online Library
Photodynamic therapy is an anti‐cancer treatment that requires illumination of
photosensitizers to induce local cell death. Current near‐infrared organic photosensitizers …

Smart molecular designs and applications of activatable organic photosensitizers

E Nestoros, A Sharma, E Kim, JS Kim… - Nature Reviews …, 2024 - nature.com
Photodynamic therapy (PDT)—which combines light, oxygen and photosensitizers (PS) to
generate reactive oxygen species—has emerged as an effective approach for targeted …

Modular synthesis of clickable peptides via late-stage maleimidation on C (7)-H tryptophan

P Wang, J Liu, X Zhu, Kenry, Z Yan, J Yan… - Nature …, 2023 - nature.com
Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to
their excellent cell penetrability, stability, thermostability, and drug-like properties. However …

Small Fluorogenic Amino Acids for Peptide‐Guided Background‐Free Imaging

F De Moliner, Z Konieczna… - Angewandte Chemie …, 2023 - Wiley Online Library
The multiple applications of super‐resolution microscopy have prompted the need for
minimally invasive labeling strategies for peptide‐guided fluorescence imaging. Many …

Nonperturbative fluorogenic labeling of immunophilins enables the wash-free detection of immunosuppressants

M Bertolini, L Mendive-Tapia, O Ghashghaei… - ACS Central …, 2024 - ACS Publications
Immunosuppressants are clinically approved drugs to treat the potential rejection of
transplanted organs and require frequent monitoring due to their narrow therapeutic …

Miniaturized chemical tags for optical imaging

S Benson, F De Moliner, W Tipping… - Angewandte Chemie …, 2022 - Wiley Online Library
Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …