Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

The main function of major histocompatibility complex (MHC) class II molecules is to present
processed antigens, which are derived primarily from exogenous sources, to CD4+ T …

Despite their importance in cell biology, the mechanisms that maintain the nucleus in its
proper position in the cell are not well understood. This is primarily the result of an …

Lysosomes are membrane‐bound cytoplasmic organelles involved in intracellular protein
degradation. They contain an assortment of soluble acid‐dependent hydrolases and a set of …

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …

Immune response to disease requires coordinated expression of an army of molecules. The
highly polymorphic MHC class I and class II molecules are key to control of specificity of …

Protein degradation, chromatin remodeling, and membrane trafficking are critically regulated
by ubiquitylation. The presence of several coexisting ubiquitin-dependent processes, each …

Using a novel approach that detects changes in the conformation of ERα, we studied the
efficacy of anti-estrogens to inactivate ERα under different experimental conditions. We …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

Although they are considered as antigen-presenting cells, the role of antigen-unspecific B
lymphocytes in antigen presentation and T-lymphocyte stimulation remains controversial. In …