Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …

The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic
and inactive heterochromatic regions of the genome,. In conventional nuclei, microscopy …

How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …

Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential
to generate a new organism. The maternal genome inherited from the oocyte and the …

The spatial organization of chromosomes influences many nuclear processes including
gene expression. The cohesin complex shapes the 3D genome by looping together CTCF …

We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and
diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 …

The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

The eukaryotic genome is organized in the three-dimensional nuclear space in a specific
manner that is both a cause and a consequence of its function. This organization is partly …