Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Previous studies implicated protein arginine methyltransferase 5 (PRMT5) as a synthetic
lethal target for MTAP-deleted (MTAP del) cancers; however, the pharmacologic …

Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and
the master transcription regulator E2F1 is an important methylation target. We have explored …

The PRMT5• MTA complex has recently emerged as a new synthetically lethal drug target
for the treatment of MTAP-deleted cancers. Here, we report the discovery of development …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Purpose: In this first-in-human, Phase 1, open-label, multicenter study, we evaluated JNJ-
64619178, a selective and potent PRMT5 inhibitor, in patients with advanced malignant …

Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …

Richter's Transformation (RT) is a poorly understood and fatal progression of chronic
lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …