Regiodivergent Organocatalytic Reactions

M Viji, S Lanka, J Sim, C Jung, H Lee, M Vishwanath… - Catalysts, 2021 - mdpi.com
Organocatalysts are abundantly used for various transformations, particularly to obtain
highly enantio-and diastereomeric pure products by controlling the stereochemistry. These …

The synthesis of O/S-heterocycles starting from β-nitrostyrenes: A recent update

C Li, K Yin, X Zhou, F Zhang, Z Shen - Tetrahedron, 2023 - Elsevier
O/S-Based heterocycles have emerged as one of the most important classes of heterocyclic
compounds and have received considerable attention because of their importance as …

N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Carbocycle-Fused Uracils via Formal [4+ 2] Annulation/Lactone Formation/Decarboxylation Cascade

C Lin, S Zhang, J Wang, L Chen, Y Zhu, D Du - Organic Letters, 2022 - ACS Publications
An unprecedented organocatalytic asymmetric construction of novel six-membered
carbocycle fused uracils has been demonstrated by the reaction of the remotely enolizable 6 …

Shaping Chirality via Stereoselective, Organocatalytic [4+2] Cycloadditions involving Heterocyclic ortho‐Quinodimethanes

E Marcantonio, C Curti - Chemistry–A European Journal, 2024 - Wiley Online Library
Polycyclic compounds bearing a complex heterocyclic core such as an aromatic heterocycle
“fused” with one or more functionalized rings, are widespread leading molecules in the …

KOtBu-Promoted [4+2] Annulation-Dehydration Cascade Enabling the Construction of Diverse 2-Pyridone-Fused Uracils

W Ha, SJ Shin, YS Ji, SW Youn - Organic Letters, 2024 - ACS Publications
A KO t Bu-promoted [4+ 2] annulation-dehydration cascade reaction has been developed,
enabling the efficient synthesis of diverse 2-pyridone-fused uracils through a vinylogous …

The Chiral 5, 6-Cyclohexane-fused Uracil Ring-System: a Molecular Platform with Promising Activity against SARS-CoV-2

E Marcantonio, D Guazzetti, C Coppa… - European Journal of …, 2025 - Elsevier
The recurrent global exposure to highly challenging viral epidemics, and the still limited
spectrum of effective pharmacological options step on the accelerator towards the …

Catalytically generated noncovalent ammonium dienolate: a versatile platform for the development of organocatalytic asymmetric cascade reactions

JB Lin, DS Ji, PF Xu - Science China Chemistry, 2024 - Springer
Organocatalytic cascade reactions represent a powerful strategy for the rapid construction of
complex chiral molecules with multiple stereocenters from simple substrates under mild …

Mechanistic Insights into the Stepwise (4+ 2) Cycloaddition toward Chiral Fused Uracil Derivatives

E Marcantonio, F Zanardi, C Curti… - Advanced Synthesis & …, 2023 - Wiley Online Library
The mechanism of the previously reported stereoselective (4+ 2) cycloaddition of N‐
protected 6‐methyluracil‐5‐carbaldehydes and (E)‐β‐nitrostyrenes catalyzed by …

Expeditious synthesis of CF 3-phenanthridones through a base-mediated cross-conjugated vinylogous benzannulation (VBA)

M Desagoni, C Nagababu, N Punna - Organic & Biomolecular …, 2025 - pubs.rsc.org
Herein, we report a mild, efficient, and rapid approach for the preparation of CF3-
phenanthridones through a cross-conjugated vinylogous [4+ 2] benzannulation of easily …

Turning the Imidazole Core into Three‐Dimensional Ring Systems: Mild Organocatalytic Entry to Enantiopure 6, 7‐Dihydrobenzimidazoles

E Marcantonio, D Guazzetti, K Bugatti… - … A European Journal, 2023 - Wiley Online Library
Organocatalytic asymmetric transformation of common aromatic heterocycles via in situ
formation of highly reactive dearomatized ortho‐quinodimethane diene species and …