[HTML][HTML] Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular …

Q Zhang, J Liu, H Duan, R Li, W Peng, C Wu - Journal of advanced …, 2021 - Elsevier
Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

Anti-carcinogenic glucosinolates in cruciferous vegetables and their antagonistic effects on prevention of cancers

P Soundararajan, JS Kim - Molecules, 2018 - mdpi.com
Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Q Xiang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

The role of Nrf2 in cardiovascular function and disease

S Satta, AM Mahmoud, FL Wilkinson… - Oxidative medicine …, 2017 - Wiley Online Library
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases

RM Kamal, AF Abdull Razis, NS Mohd Sukri… - Molecules, 2022 - mdpi.com
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that
affect the nervous system and heart, all of which are vital to the human body. To maintain …

TrxR1 as a potent regulator of the Nrf2-Keap1 response system

M Cebula, EE Schmidt, ESJ Arnér - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

Sulforaphane protects against cardiovascular disease via Nrf2 activation

Y Bai, X Wang, S Zhao, C Ma, J Cui… - Oxidative medicine and …, 2015 - Wiley Online Library
Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of
disease and will remain the main cause of mortality for the near future. Oxidative stress plays …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

[HTML][HTML] Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and …

C Li, WJ Zhang, B Frei - Redox biology, 2016 - Elsevier
Atherosclerosis, the underlying cause of ischemic heart disease and stroke, is an
inflammatory disease of arteries in a hyperlipidemic milieu. Endothelial expression of …

Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseases

Z Guo, Z Mo - Journal of Tissue Engineering and Regenerative …, 2020 - Wiley Online Library
The transcription factor, nuclear factor E2‐related factor 2 (Nrf2), is highly sensitive to
oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen …