Anatomical, physiological, and functional diversity of adipose tissue

RK Zwick, CF Guerrero-Juarez, V Horsley, MV Plikus - Cell metabolism, 2018 - cell.com
Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

Mechanisms that underly T cell immunity in graves' orbitopathy

S Fang, Y Lu, Y Huang, H Zhou, X Fan - Frontiers in Endocrinology, 2021 - frontiersin.org
Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is the most
common ocular abnormality of Graves' disease. It is a disfiguring, invalidating, and …

HIF2A–LOX pathway promotes fibrotic tissue remodeling in thyroid-associated orbitopathy

F Hikage, S Atkins, A Kahana, TJ Smith… - Endocrinology, 2019 - academic.oup.com
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease
associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which …

Predicting the course of Graves' orbitopathy using serially measured TSH-receptor autoantibodies by automated binding immunoassays and the functional bioassay

M Stöhr, M Oeverhaus, SD Lytton… - Hormone and …, 2021 - thieme-connect.com
The aim of the study was to investigate the use of serial measurements of TSH-receptor
autoantibodies (TRAb) with the newest available assay technology to predict the course of …

Molecular biomarkers of Graves' ophthalmopathy

CM Longo, PJ Higgins - Experimental and molecular pathology, 2019 - Elsevier
Abstract Graves' ophthalmopathy (GO), a complication of Graves' disease (GD), is typified by
orbital inflammation, ocular tissue expansion and remodeling and, ultimately, fibrosis. Orbital …

Graves' orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model

A Schlüter, U Flögel, S Diaz-Cano, GE Görtz, K Stähr… - Scientific reports, 2018 - nature.com
Graves' orbitopathy (GO) is the most common extra thyroidal complication of Graves' disease
(GD) and occurs predominantly in women but more severe in men. The reason for this effect …

Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' …

A Schlüter, M Horstmann, S Diaz-Cano… - Clinical & …, 2018 - academic.oup.com
Experimental models of Graves' hyperthyroid disease accompanied by Graves' orbitopathy
(GO) can be induced efficiently in susceptible inbred strains of mice by immunization by …

Sphingolipids in thyroid eye disease

A Gulbins, GE Görtz, E Gulbins… - Frontiers in Endocrinology, 2023 - frontiersin.org
Graves' disease (GD) is caused by an autoimmune formation of autoantibodies and
autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR). The …

Thinking inside the box: Current insights into targeting orbital tissue remodeling and inflammation in thyroid eye disease

V Gupta, CL Hammond, E Roztocil, MO Gonzalez… - Survey of …, 2022 - Elsevier
Thyroid eye disease (TED) is an autoimmune disorder that manifests in the orbit. In TED, the
connective tissue behind the eye becomes inflamed and remodels with increased fat …

Differential expression and alternative splicing of transcripts in orbital adipose/connective tissue of thyroid-associated ophthalmopathy

L Wu, Y Liang, N Song, X Wang… - Experimental …, 2021 - journals.sagepub.com
Thyroid-associated ophthalmopathy is a typical autoimmune disease of orbital tissues.
Alternative splicing significantly influences many diseases progression, including cancer …