Editorial focus: understanding off-target effects as the key to successful RNAi therapy
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
The implications of ncRNAs in the development of human diseases
E López-Jiménez, E Andrés-León - Non-coding RNA, 2021 - mdpi.com
The mammalian genome comprehends a small minority of genes that encode for proteins
(barely 2% of the total genome in humans) and an immense majority of genes that are …
(barely 2% of the total genome in humans) and an immense majority of genes that are …
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
A Arnau-Soler, E Macdonald-Dunlop, MJ Adams… - Translational …, 2019 - nature.com
Stress is associated with poorer physical and mental health. To improve our understanding
of this link, we performed genome-wide association studies (GWAS) of depressive …
of this link, we performed genome-wide association studies (GWAS) of depressive …
Emerging roles of PIWI-interacting RNAs (piRNAs) and PIWI proteins in head and neck cancer and their potential clinical implications
Head and neck squamous cell carcinoma (HNSCC) are among the well-known neoplasms
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …
Editorial focus: entering into the non-coding RNA era
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2018 - Springer
Recent developments in high-throughput genotyping technologies have revealed the
existence of several new classes of RNA that do not encode proteins but serve other cellular …
existence of several new classes of RNA that do not encode proteins but serve other cellular …
OTX Genes in Adult Tissues
A Terrinoni, G Micheloni, V Moretti, S Caporali… - International Journal of …, 2023 - mdpi.com
OTX homeobox genes have been extensively studied for their role in development,
especially in neuroectoderm formation. Recently, their expression has also been reported in …
especially in neuroectoderm formation. Recently, their expression has also been reported in …
Small RNA proteome as disease biomarker: an incognito treasure of clinical utility
The discovery of small non-coding RNAs such as microRNAs (miRNAs), small interfering
RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs) in recent years has divulged as the …
RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs) in recent years has divulged as the …
A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML
RNA-binding proteins (RBPs) form a large and diverse class of factors, many members of
which are overexpressed in hematologic malignancies. RBPs participate in various …
which are overexpressed in hematologic malignancies. RBPs participate in various …
[HTML][HTML] Mechanisms Behind the Impact of PIWI Proteins on Cancer Cells: Literature Review
P Limanówka, B Ochman… - International Journal of …, 2024 - mdpi.com
The P-Element-induced wimpy testis (PIWI) group of proteins plays a key role in RNA
interference, particularly in the regulation of small non-coding RNAs. However, in recent …
interference, particularly in the regulation of small non-coding RNAs. However, in recent …
The effects of single nucleotide polymorphisms in cancer RNAi therapies
M Gebert, M Jaśkiewicz, A Moszyńska, JF Collawn… - Cancers, 2020 - mdpi.com
Simple Summary Despite the recent progress in RNAi delivery of siRNA-based therapeutics
for cancer therapy, the presence of single nucleotide polymorphisms (SNPs) in the general …
for cancer therapy, the presence of single nucleotide polymorphisms (SNPs) in the general …