Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …

Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical
and psychiatric conditions such as forms of obesity and eating disorders. Although feeding …

Urges to eat are influenced by stimuli in the environment that are associated with food (food
cues). Obese people are more sensitive to food cues, reporting stronger craving and …

Both cigarette smoking and obesity are significant public health concerns and are
associated with increased risk of early mortality. It is well established that the mesolimbic …

Rationale The recruitment of the stress circuitry contributes to a shift from positive to negative
reinforcement mechanisms sustaining long-term cocaine addiction. The kappa opioid …

Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D
2/3 R) non-selective antagonist tracers suggests that obese (OB) individuals exhibit lower D …

Obesity is one of the leading causes of preventable illness in the US. The ability to seek out
and find food relies in large part on activation on mesocorticolimbic regions including the …

Rationale Basal and diet-induced differences in mesolimbic function, particularly within the
nucleus accumbens (NAc), may contribute to human obesity; these differences may be more …

Obesity is a growing global epidemic that stems from the increasing availability of highly-
palatable foods and the consequent enhanced calorie consumption. Extensive research has …

Obesity is a significant problem in the United States, with roughly one third of adults having a
body mass index (BMI) over thirty. Recent evidence from human studies suggests that pre …