Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation,
increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very …

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …

Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to organ
fibrogenesis. We have reported that N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) restored …

The renin-angiotensin system (RAS) plays a crucial role in cardiovascular regulations and
its modulation is a challenging target for the vast majority of cardioprotective strategies …

Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the
pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct …

Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to organ
fibrogenesis, and we have reported that the anti-EndMT effect of N-acetyl-seryl-aspartyl-lysyl …

The renin–angiotensin–aldosterone system (RAAS) ranks among the most challenging
puzzles in cardiovascular medicine. It participates in the principal homeostatic mechanisms …

Abstract N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous tetrapeptide with
potential antifibrotic effect. However, the underlying mechanism in the anti-fibrosis is still …

We determined the efficacy and safety of 0.1% RGN-259 ophthalmic solution (containing the
regenerative protein thymosin ß4) in promoting the healing of persistent epithelial defects in …

Abstract Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective
renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute …