Phosphorothioates have found their usefulness in the general area of oligonucleotide
therapeutic applications. Initially this modification was introduced into the antisense …

There has been an upsurge in the number of clinical trials involving chemically modified
oligonucleotide-based drug candidates after the FDA approval of Vitravene, Macugen, and …

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is
replaced by a sulphur atom, share similar physical and chemical properties with …

Two waterworks, with source water derived from the Huangpu or Yangtze River in Shanghai,
were investigated, and the effluents were plate-screened for antibiotic-resistant bacteria …

Phosphorus is an element critical to the formation of several biomolecules, including nucleic
acids, the energy transfer molecule ATP, and phospholipids. It hence lies at the heart of …

The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment
has led to a significant issue with pathogen resistance worldwide over the past decades …

Life on Earth is known to rarely make fluorinated carbon compounds, as compared to other
halocarbons. We quantify this rarity, based on our exhaustive natural products database …

DNA modifications, such as methylation guide numerous critical biological processes, yet
epigenetic information has not routinely been collected as part of DNA sequence analyses …

Phosphorous-containing molecules are essential constituents of all living cells. While the
phosphate functional group is very common in small molecule natural products, nucleic …

Abstract Mcr-1 and bla NDM-1 antibiotic resistance genes (ARGs) confer resistance to
colistins and carbapenems, which are often antibiotics used as a last resort in tertiary care …