Parathyroid hormone (PTH) exerts profound effects on skeletal homeostasis through
multiple cellular and molecular mechanisms. Continuous hyperparathyroidism causes net …

Osteocytes are the most abundant cell type in bone and play a central role in orchestrating
skeletal remodeling, in part by producing paracrine acting factors that in turn influence …

We have previously shown that parathyroid hormone (PTH) induces the phosphorylation of
the DNA-binding protein Nascent polypeptide associated complex And Coregulator alpha …

The ubiquitin-proteasome system regulates biological processes in normal and diseased
states. Recent investigations have focused on ubiquitin-dependent modifications and their …

In the nucleus of differentiated osteoblasts, the alpha chain of nascent polypeptide
associated complex (αNAC) interacts with cJUN transcription factors to regulate the …

The 11 existing FDA-approved osteoporosis drug treatments include hormone replacement
therapy, 2 SERMs (raloxifene and bazedoxifene), 5 inhibitors of bone-resorbing osteoclasts …

PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through
Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene …

L'injection quotidienne d'hormone parathyroïdienne (PTH) augmente la masse osseuse
etprotège contre les fractures ostéoporotiques. Cependant, le mécanisme d'action n'est …

The daily injection of parathyroid hormone (PTH) increases bone mass and protectsagainst
osteoporotic fractures, however a complete picture of its mechanism of action is stillmissing …