Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

In the area of biomaterials, there has been recent activity in the use of micro-and
nanofabrication technology to alter material surfaces for influencing the attachment and …

Nanotechnology has provided methods to fabricate surface patterns with features down to a
few nm. If cells or cell processes exhibit contact guidance in response to such small patterns …

Having the ability to control cell behaviour would be of great advantage in tissue
engineering. One method of gaining control over cell adhesion, proliferation, guidance and …

In order for cells to react to topography, they must be able to sense shape. When
considering nano-topography, these shapes are much smaller than the cell, but still strong …

Extracellular matrix molecules provide biochemical and topographical cues that influence
cell growth in vivo and in vitro. Effects of topographical cues on hippocampal neuron growth …

This review discusses the design of scaffolds having submicron and nanoscale features for
neural-engineering applications. In particular, the goal is to create materials that can …

Control of the cells' nanoenvironment is likely to be important in the future of cell and tissue
engineering. Microtopography has been shown to provide cues to cells that elicit a large …

We explore textural cues as a mechanism for controlling neuronal process outgrowth in
primary cultures of mammalian neurons. The work uses a form of decal transfer lithography …

This review looks at the present literature available regarding cell response to nano-islands
produced by nanotopography. Polymer demixing is a chemical method of fabricating large …