Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Recent breakthroughs in regenerative medicine have generated enthusiasm and many
efforts to explore new therapeutic potentials of both somatic and pluripotent stem cells …

Limbal epithelial stem cell (LESC) deficiency (LSCD) leads to corneal abnormalities
resulting in compromised vision and blindness. LSCD can be potentially treated by …

Objective Human amniotic membrane (HAM) is used as a supporter for limbal stem cell
(LSC) expansion and corneal surgery. The aim of study is to use HAM extracts from healthy …

Corneal integrity is essential for visual function. Transplantation remains the most common
treatment option for advanced corneal diseases. A global donor material shortage requires a …

Niche factors are important in the maintenance and regulation of stem cells. Limbal stromal
cells are potentially a component of limbal stem cell (LSC) niche. We investigated the role of …

A simple, reproducible, animal-material free method for cultivating and characterizing
cornea limbal epithelial stem cells (LESCs) on human lens capsule (LC) was developed for …

Currently, many corneal diseases are treated by corneal transplantation, artificial corneal
implantation or, in severe cases, keratoprosthesis. Owing to the shortage of cornea donors …

Limbal stem cell deficiency is a painful and potentially blinding disease. Cultured limbal
epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction …

PURPOSE Taking into consideration prior human experience with treating limbal stem cell
deficiency (LSCD) with cultivated limbal epithelial cells (CLEC) from other countries, we …