In the next-generation sequencing era, RT-qPCR is still widely employed to quantify levels
of nucleic acids of interest due to its popularity, versatility, and limited costs. The …

Aortic aneurysm is a complex multifactorial disease, and its molecular mechanism is not
understood. In thoracic aortic aneurysm (TAA), the expansion of the aortic wall is lead by …

Background: Thoracic aortic dissections (TAD) are life-threatening events mostly requiring
immediate surgical treatment. Although dissections mainly occur independently of thoracic …

Background Ascending thoracic aortic aneurysm (ATAA) is a major cause of morbidity and
mortality worldwide. The pathogenesis of medial degeneration of the aorta remains …

Quantitative polymerase chain reaction (qPCR) is the most specific and reliable method for
determination of mRNA gene expression. Crucial point for its accurate normalization is the …

Objectives Certain aortic valve malformations predispose to ascending aortic aneurysm,
although the mechanisms are incompletely understood. The aim of this study was to …

Bicuspid aortic valve (BAV) disease is the most common congenital cardiac abnormality and
predisposes patients to life-threatening aortic complications including aortic aneurysm …

Background The pathogenesis of aortic dilatation in patients with congenital aortic valve
anomalies is poorly understood. Recent studies suggest that alterations of gene expression …

Chronic kidney disease (CKD) greatly increases the risk for cardiovascular disease (CVD).
However, molecular mechanisms underlying CKD-induced arterial remodeling are largely …

Dilatation of the ascending aorta (AAD) is a prevalent aortopathy that occurs frequently
associated with bicuspid aortic valve (BAV), the most common human congenital cardiac …