Type II topoisomerases regulate DNA topology by making a double-stranded break in one
DNA duplex, transporting another DNA segment through this break and then resealing it …

Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …

Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …

The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-
spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens …

The emergence of bacterial resistance against life-saving medicines has forced the scientific
community and pharmaceutical industry to take actions in the quest for novel antibacterials …

Since 2000, some thirteen quinolones and fluoroquinolones have been developed and
have come to market. The quinolones, one of the most successful classes of antibacterial …

Due to the ever‐increasing antimicrobial resistance there is an urgent need to continuously
design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities …

Bacterial DNA gyrase and topoisomerase IV inhibition has emerged as a promising strategy
for the cure of infections caused by antibiotic-resistant bacteria. Small molecule …

Objective: To evaluate the antifungal activity of hydralazine hydrochloride alone and in
synergy with azoles against Candida spp. and the action mechanism. Methods: We used …

During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type
II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic …