The number of druggable tumor-specific molecular aberrations has grown substantially in
the past decade, with a significant survival benefit obtained from biomarker matching …

Functional analysis of large gene lists, derived in most cases from emerging high-throughput
genomic, proteomic and bioinformatics scanning approaches, is still a challenging and …

VSMCs respond to changes in the local environment by adjusting their phenotype from
contractile to synthetic, a phenomenon known as phenotypic modulation or switching …

We have developed GoMiner, a program package that organizes lists of'interesting'genes
(for example, under-and overexpressed genes from a microarray experiment) for biological …

The functioning of even a simple biological system is much more complicated than the sum
of its genes, proteins and metabolites. A premise of systems biology is that molecular …

Background Studies integrating transcriptomic data with proteomic data can illuminate the
proteome more clearly than either separately. Integromic studies can deepen understanding …

Because most potential molecular markers and targets are proteins, proteomic profiling is
expected to yield more direct answers to functional and pharmacological questions than …

The dynamic expression of AMPA-type glutamate receptors (AMPA-R) at synapses is a key
determinant of synaptic plasticity, including neuroadaptations to drugs of abuse. Recently …

To evaluate the utility of transcript profiling for prediction of protein expression levels, we
compared profiles across the NCI-60 cancer cell panel, which represents nine tissues of …

A fraction of liver transplant recipients are able to discontinue all immunosuppressive
therapies without rejecting their grafts and are said to be operationally tolerant to the …