Susceptibility‐weighted imaging: current status and future directions

S Liu, S Buch, Y Chen, HS Choi, Y Dai… - NMR in …, 2017 - Wiley Online Library
Susceptibility‐weighted imaging (SWI) is a method that uses the intrinsic nature of local
magnetic fields to enhance image contrast in order to improve the visibility of various …

Mitochondrial dynamics: a potential therapeutic target for ischemic stroke

X Zhou, H Chen, L Wang, C Lenahan, L Lian… - Frontiers in Aging …, 2021 - frontiersin.org
Stroke is one of the leading causes of death and disability worldwide. Brain injury after
ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress …

Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia

LC Jordan, MC Gindville, AO Scott, MR Juttukonda… - Brain, 2016 - academic.oup.com
Sickle cell anaemia is a monogenetic disorder with a high incidence of stroke. While stroke
screening procedures exist for children with sickle cell anaemia, no accepted screening …

Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia

KP Guilliams, ME Fields, DK Ragan… - Blood, The Journal …, 2018 - ashpublications.org
Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia
(SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …

Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

MJ Donahue, E Achten, PM Cogswell… - Journal of Cerebral …, 2018 - journals.sagepub.com
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of
adult disability in most developed countries. This work summarizes state-of-the-art, and …

pH-sensitive MRI demarcates graded tissue acidification during acute stroke―pH specificity enhancement with magnetization transfer and relaxation-normalized …

Y Guo, IY Zhou, ST Chan, Y Wang, ET Mandeville… - Neuroimage, 2016 - Elsevier
Abstract pH-sensitive amide proton transfer (APT) MRI provides a surrogate metabolic
biomarker that complements the widely-used perfusion and diffusion imaging. However, the …

Cerebral metabolic rate of oxygen (CMRO2) mapping with hyperventilation challenge using quantitative susceptibility mapping (QSM)

J Zhang, D Zhou, TD Nguyen… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose Our objective was to demonstrate the feasibility of using hyperventilation as an
efficient vasoconstrictive challenge and prior knowledge as denoising constraints for …

Diffusion kurtosis imaging of acute infarction: comparison with routine diffusion and follow-up MR imaging

J Yin, H Sun, Z Wang, H Ni, W Shen, PZ Sun - Radiology, 2018 - pubs.rsna.org
Purpose To determine the relationship between diffusion-weighted imaging (DWI) and
diffusion kurtosis imaging (DKI) in patients with acute stroke at admission and the tissue …

Oxygen metabolism in acute ischemic stroke

W Lin, WJ Powers - Journal of Cerebral Blood Flow & …, 2018 - journals.sagepub.com
Gaining insights into brain oxygen metabolism has been one of the key areas of research in
neurosciences. Extensive efforts have been devoted to developing approaches capable of …