Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

[HTML][HTML] Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms

S Summonte, GF Racaniello, A Lopedota… - Journal of Controlled …, 2021 - Elsevier
This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated
hyaluronic acid, chitosan, cyclodextrin, poly (ethylene glycol) and dextran that are cross …

Peptide-and protein-based hydrogels

AM Jonker, DWPM Löwik… - Chemistry of …, 2012 - ACS Publications
Hydrogels are polymeric networks, capable of absorbing large amounts of water and
biological fluids. They are insoluble due to the presence of chemical or physical cross-links …

Temperature-responsive supramolecular hydrogels

S Xian, MJ Webber - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Hydrogels comprise a class of soft materials which are extremely useful in a number of
contexts, for example as matrix-mimetic biomaterials for applications in regenerative …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

Extracellular matrix‐mimetic hydrogels for treating neural tissue injury: a focus on fibrin, hyaluronic acid, and elastin‐like polypeptide hydrogels

DW Nelson, RJ Gilbert - Advanced healthcare materials, 2021 - Wiley Online Library
Neurological and functional recovery is limited following central nervous system injury and
severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic …

Collagen and elastin biomaterials for the fabrication of engineered living tissues

D Miranda-Nieves, EL Chaikof - ACS Biomaterials Science & …, 2017 - ACS Publications
Collagen and elastin represent the two most predominant proteins in the body and are
responsible for modulating important biological and mechanical properties. Thus, the focus …

Engineered protein hydrogels as biomimetic cellular scaffolds

Y Liu, AE Gilchrist, SC Heilshorn - Advanced Materials, 2024 - Wiley Online Library
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …

Opportunities for multicomponent hybrid hydrogels in biomedical applications

HK Lau, KL Kiick - Biomacromolecules, 2015 - ACS Publications
Hydrogels provide mechanical support and a hydrated environment that offer good
cytocompatibility and controlled release of molecules, and myriad hydrogels thus have been …

Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple …

C Hu, X Liu, W Ran, J Meng, Y Zhai, P Zhang, Q Yin… - Biomaterials, 2017 - Elsevier
Preoperative chemotherapy is effective in improving the prognosis of patients, but its efficacy
is impeded by cancer associated fibroblasts (CAFs) that enhance the survival, growth, and …