Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …

Transcriptional enhancers are crucial regulators of gene expression and animal
development and the characterization of their genomic organization, spatiotemporal …

In animals, Hox transcription factors define regional identity in distinct anatomical domains.
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …

Biologists have long sought to understand which genes and what kinds of changes in their
sequences are responsible for the evolution of morphological diversity. Here, I outline eight …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

Development of the animal body plan is controlled by large gene regulatory networks
(GRNs), and hence evolution of body plans must depend upon change in the architecture of …

Secreted signals, known as morphogens, provide the positional information that organizes
gene expression and cellular differentiation in many developing tissues. In the vertebrate …

The genomic program for development operates primarily by the regulated expression of
genes encoding transcription factors and components of cell signaling pathways. This …