Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
The role and therapeutic targeting of JAK/STAT signaling in glioblastoma
A Ou, M Ott, D Fang, AB Heimberger - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …
and despite techniques that have allowed scientists and clinicians to better understand the …
Role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance
Recent efforts in brain tumor research have been directed towards the modulation of the
immune system for therapeutic interventions. Several human cancers, including gliomas, are …
immune system for therapeutic interventions. Several human cancers, including gliomas, are …
Electrotherapies for glioblastoma
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …
The glioblastoma microenvironment: morphology, metabolism, and molecular signature of glial dynamics to discover metabolic rewiring sequence
A Virtuoso, R Giovannoni, C De Luca… - International Journal of …, 2021 - mdpi.com
Different functional states determine glioblastoma (GBM) heterogeneity. Brain cancer cells
coexist with the glial cells in a functional syncytium based on a continuous metabolic …
coexist with the glial cells in a functional syncytium based on a continuous metabolic …
Pathogenetic features and current management of glioblastoma
Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …
Ferroptosis involvement in glioblastoma treatment
AO Mitre, AI Florian, A Buruiana, A Boer, I Moldovan… - Medicina, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is one of the deadliest brain tumors. Current standard
therapy includes tumor resection surgery followed by radiotherapy and chemotherapy. Due …
therapy includes tumor resection surgery followed by radiotherapy and chemotherapy. Due …
New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4
PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of
arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down‐regulation of …
arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down‐regulation of …
Bridging radiotherapy to immunotherapy: the IFN–JAK–STAT Axis
LZ Shi, JA Bonner - International Journal of Molecular Sciences, 2021 - mdpi.com
The unprecedented successes of immunotherapies (IOs) including immune checkpoint
blockers (ICBs) and adoptive T-cell therapy (ACT) in patients with late-stage cancer provide …
blockers (ICBs) and adoptive T-cell therapy (ACT) in patients with late-stage cancer provide …
[HTML][HTML] The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PADI4 in cancer cells
S Araujo-Abad, M Fuentes-Baile, B Rizzuti… - International Journal of …, 2023 - Elsevier
RYBP (Ring1 and YY 1 binding protein) is a multifunctional, intrinsically disordered protein
(IDP), best described as a transcriptional regulator. It exhibits a ubiquitin-binding …
(IDP), best described as a transcriptional regulator. It exhibits a ubiquitin-binding …