De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases

Y Sui, L Qi, K Zhang, N Saini… - Proceedings of the …, 2020 - National Acad Sciences
Yeast strains with low levels of the replicative DNA polymerases (alpha, delta, and epsilon)
have high levels of chromosome deletions, duplications, and translocations. By examining …

Assessment of genotoxic chemicals using chemogenomic profiling based on gene-knockout library in Saccharomyces cerevisiae

M Guan, Z Zhu, Y Jiang, M Tian, L Yan, X Xu, S Li… - Toxicology in Vitro, 2022 - Elsevier
Understanding the adverse effects of genotoxic chemicals and identifying them effectively
from non-genotoxic chemicals are of great worldwide concerns. Here, Saccharomyces …

Experimental evolution of Saccharomyces cerevisiae for caffeine tolerance alters multidrug resistance and target of rapamycin signaling pathways

RC Geck, NG Moresi, LM Anderson… - G3: Genes …, 2024 - academic.oup.com
Caffeine is a natural compound that inhibits the major cellular signaling regulator target of
rapamycin (TOR), leading to widespread effects including growth inhibition. Saccharomyces …

Live-cell assays reveal selectivity and sensitivity of the multidrug response in budding yeast

E Vanacloig-Pedros, C Lozano-Pérez, B Alarcón… - Journal of Biological …, 2019 - ASBMB
Pleiotropic drug resistance arises by the enhanced extrusion of bioactive molecules and is
present in a wide range of organisms, ranging from fungi to human cells. A key feature of this …

The polymorphic PolyQ tail protein of the mediator complex, MED15, regulates the variable response to diverse stresses

JEG Gallagher, SL Ser, MC Ayers, C Nassif… - International Journal of …, 2020 - mdpi.com
The Mediator is composed of multiple subunits conserved from yeast to humans and plays a
central role in transcription. The tail components are not required for basal transcription but …

Deregulation of the 19S proteasome complex increases yeast resistance to 4-NQO and oxidative stress via upregulation of Rpn4-and proteasome-dependent stress …

DS Karpov, DS Spasskaya, NI Nadolinskaia… - FEMS yeast …, 2019 - academic.oup.com
The 26S proteasome participates in cell stress responses via its ability to degrade regulatory
and damaged proteins. In yeast, mutations in the subunits of the 19S proteasome regulatory …

Toxicity and assimilation of cellulosic copper nanoparticles require α-arrestins in S. cerevisiae

NPD Nurmalasari, MJ Winans, K Perroz… - Metallomics, 2023 - academic.oup.com
The increased use of antimicrobial compounds such as copper into nanoparticles changes
how living cells interact with these novel materials. The increased use of antimicrobial …

[HTML][HTML] Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways

RC Geck, NG Moresi, LM Anderson, R Brewer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Caffeine is a natural compound that inhibits the major cellular signaling regulator TOR,
leading to widespread effects including growth inhibition. S. cerevisiae yeast can adapt to …

Effects of MCHM on yeast metabolism

A Pupo, KM Ku, JEG Gallagher - PLoS One, 2019 - journals.plos.org
On January 2014 approximately 10,000 gallons of crude 4-Methylcyclohexanemethanol
(MCHM) and propylene glycol phenol ether (PPH) were accidentally released into the Elk …