The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …

Over the past 3 billion years, an endogenous circadian rhythmicity has developed in almost
all life forms in which daily oscillations in physiology occur. This allows for anticipation of …

Background Metastasis is an important factor in the poor prognosis of breast cancer. As an
important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to …

Background: Night-shift work, exposure to artificial light-at-night (ALAN) and particularly blue
light spectrum, and the consequent circadian disruption may increase the risk of breast and …

Summary Period3 (Per3) is one of the most robustly rhythmic genes in humans and animals.
It plays a significant role in temporal organisation in peripheral tissues. The effects of PER3 …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Melatonin is one of the most phylogenetically conserved signals in biology. Although its
original function was probably related to its antioxidant capacity, this indoleamine has been …

Peroxisome proliferator-activated receptors (PPARs) are a class of transcription factors that
belong to the nuclear hormone receptor superfamily, and their activities are dependent on …

Background The identification of new biomarkers and the development of novel, targetable
contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal …

Background & Aims The circadian clock is crucial for physiological homeostasis including
gut homeostasis. Disorder of the circadian clock may contribute to many diseases including …