Over the past decade, immunotherapy has become a powerful and evident tool in the fight
against cancers. Notably, the rise of checkpoint blockade using monoclonal antibodies (anti …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

Thirty-five years ago, precision-cut liver slices (PCLS) were described as a promising tool
and were expected to become the standard in vitro model to study liver disease as they tick …

Present approaches to assess cancer treatments are often inaccurate, costly, and/or
cumbersome. Functional testing platforms that use live tumor cells are a promising tool both …

Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …

The normal functioning of every cell in the body depends on its bioelectric properties and
many diseases are caused by genetic and/or epigenetic dysregulation of the underlying ion …

Precision medicine approaches that inform clinical management of individuals with cancer
are progressively advancing. Patient-derived explants (PDEs) provide a patient-proximal ex …

The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the
assumption that the structures under study will perform at the best in vitro if cultivated in an …