Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems

MJ Langton - Nature Reviews Chemistry, 2021 - nature.com
The membrane proteins found in nature control many important cellular functions, including
signal transduction and transmembrane ion transport, and these, in turn, are regulated by …

Self‐assembled artificial ion‐channels toward natural selection of functions

S Zheng, L Huang, Z Sun… - Angewandte Chemie …, 2021 - Wiley Online Library
Owing to their significant physiological functions, especially as selective relays for
translocation of physiological relevant species through cellular membranes, natural ion …

Anion transport with chalcogen bonds

S Benz, M Macchione, Q Verolet… - Journal of the …, 2016 - ACS Publications
In this report, we introduce synthetic anion transporters that operate with chalcogen bonds.
Electron-deficient dithieno [3, 2-b; 2′, 3′-d] thiophenes (DTTs) are identified as ideal to …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

Photo‐and Redox‐Regulated Transmembrane Ion Transporters

M Ahmad, SA Gartland… - Angewandte Chemie …, 2023 - Wiley Online Library
Synthetic supramolecular ion transporters find applications as potential therapeutics and as
tools for engineering functional membranes. Stimuli‐responsive systems enable external …

A photo-responsive transmembrane anion transporter relay

TG Johnson, A Sadeghi-Kelishadi… - Journal of the American …, 2022 - ACS Publications
Ion transport across lipid membranes in biology is controlled by stimuli-responsive
membrane channels and molecular machine ion pumps such as ATPases. Here, we report a …

Engineering smart nanofluidic systems for artificial ion channels and ion pumps: from single‐pore to multichannel membranes

Z Zhang, X Huang, Y Qian, W Chen, L Wen… - Advanced …, 2020 - Wiley Online Library
Biological ion channels and ion pumps with intricate ion transport functions widely exist in
living organisms and play irreplaceable roles in almost all physiological functions …

Supramolecular mechanosensitive potassium channel formed by fluorinated amphiphilic cyclophane

K Sato, R Sasaki, R Matsuda… - Journal of the …, 2022 - ACS Publications
Inspired by mechanosensitive potassium channels found in nature, we developed a
fluorinated amphiphilic cyclophane composed of fluorinated rigid aromatic units connected …

Chloride transport through supramolecular barrel-rosette ion channels: lipophilic control and apoptosis-inducing activity

T Saha, A Gautam, A Mukherjee, M Lahiri… - Journal of the …, 2016 - ACS Publications
Despite the great interest in artificial ion channel design, only a small number of channel-
forming molecules are currently available for addressing challenging problems, particularly …

Supramolecular transmembrane ion channels formed by multiblock amphiphiles

K Sato, T Muraoka, K Kinbara - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Transmembrane proteins located within biological membranes play a crucial
role in a variety of important cellular processes, such as energy conversion and signal …