Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells
can be generated to mimic embryogenesis in vitro. However, the assembly system and …

Human pluripotent stem cell-derived liver organoids (HLOs) have recently become a
promising alternative for liver regenerative therapy. To realize this application, a large …

The pluripotency of stem cells determines their developmental potential. While the
pluripotency states of pluripotent stem cells are variable and interconvertible, the …

Cattle have emerged as one of the most important domestic animals widely used for meat,
milk, and fur. Derivation of bovine pluripotent stem cells (PSCs) can be applied in drug …

Bovine embryonic stem cells (ESC) have features associated with the primed pluripotent
state including low expression of one of the core pluripotency transcription factors, NANOG …

The preimplantation mammalian (including mouse and human) embryo holds remarkable
regulatory abilities, which have found their application, for example, in the preimplantation …

Maternal obesity (MO) predisposes offspring to metabolic disorders, but the mechanisms
remain poorly defined. Recent studies emphasize the importance of brown adipose tissue …

In this work, we aimed to determine the role of activin A during crucial events of mouse
embryogenesis and distinguish the function of the protein of zygotic origin and the one …

A better understanding of the mechanisms of beige and brown adipogenesis is needed for
developing strategies to prevent and treat obesity and associated metabolic disorders …

The human pluripotent stem cells-derived liver organoid (HLOs) has recently become a
promising alternative source for liver regenerative therapy. To realize this application, a …