Tumor-draining lymph nodes: At the crossroads of metastasis and immunity
Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis
H Zhou, M Wang, Y Zhang, Q Su, Z Xie… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
[PDF][PDF] Molecular engineering of AIE luminogens for NIR-II/IIb bioimaging and surgical navigation of lymph nodes
Sentinel lymph node (SLN) imaging is vital for tumor staging and treatment decision-making,
and current methods for SLN imaging suffer from a short retention time, poor penetration …
and current methods for SLN imaging suffer from a short retention time, poor penetration …
[HTML][HTML] A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC
LB Darragh, MM Knitz, J Hu, ET Clambey, J Backus… - Nature Cancer, 2022 - nature.com
Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …
carcinomas remain below 50%. We assessed the safety of administering combination …
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models
M Datta, S Chatterjee, EM Perez… - Proceedings of the …, 2023 - National Acad Sciences
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …
[HTML][HTML] Fueling sentinel node via reshaping cytotoxic T lymphocytes with a flex-patch for post-operative immuno-adjuvant therapy
Clinical updates suggest conserving metastatic sentinel lymph nodes (SLNs) of breast
cancer (BC) patients during surgery; however, the immunoadjuvant potential of this strategy …
cancer (BC) patients during surgery; however, the immunoadjuvant potential of this strategy …
Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission
In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking
and tumour infiltration of immune cells. Understanding such consequences and the origin of …
and tumour infiltration of immune cells. Understanding such consequences and the origin of …
The peritumor microenvironment: physics and immunity
Cancer initiation and progression drastically alter the microenvironment at the interface
between healthy and malignant tissue. This site, termed the peritumor, bears unique …
between healthy and malignant tissue. This site, termed the peritumor, bears unique …
Interstitial fluid pressure as an emerging biomarker in solid tumors
The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …
Mechano-modulation of T cells for cancer immunotherapy
Immunotherapy, despite its promise for future anti-cancer approach, faces significant
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …