Background New synthetic opioids (NSO) constitute one of the fastest-growing group of New
Psychoactive Substances, which emerged on the illicit drug marker in the second half of …

Since the early 2010s, synthetic opioids have significantly contributed to overall opioid-
related overdose mortalities. For point of reference, of the 68,630 opioid-related deaths …

Introduction Prohibited drugs in unregulated markets may be adulterated, resulting in
increased risks for people who use drugs. This study investigated levels of drug adulteration …

Following isotonitazene scheduling in 2019, the availability of alternative 2-
benzylbenzimidazole opioids (nitazenes) on the global drug market increased, resulting in …

Background New psychoactive substances (NPS) are of public health concern due to their
sporadic proliferation and the dearth of information on toxicity when consumed. In addition to …

Abstract Introduction The Emerging Drugs Network of Australia–Victoria (EDNAV) project is
a newly established toxicosurveillance network that collates clinical and toxicological data …

The detection of nitazenes in biological fluids is increasingly needed as they are repeatedly
reported in intoxication and overdose cases. A simple method for the quantification of low …

Four nitazenes (metonitazene, etonitazene, protonitazene, and isotonitazene), highly potent
benzimidazole synthetic opioids, and their four nitro group positional isomers (isonitazenes) …

Abstract Background 2-Benzylbenzimidazole 'nitazene'opioids pose a growing threat to
public health. Nitazene analogues are increasingly found mixed with or (mis) sold as heroin …

The emergence of 2-benzylbenzimidazole “nitazene” opioids is stirring up the recreational
synthetic opioid market. Many nitazene analogues act as potent agonists at the µ‑opioid …