Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis
A decline in skeletal muscle mass and low muscular strength are prognostic factors in
advanced human cancers. Here we found that breast cancer suppressed O-linked N …
advanced human cancers. Here we found that breast cancer suppressed O-linked N …
Targeting O-GlcNAcylation to develop novel therapeutics
Y Zhu, GW Hart - Molecular aspects of medicine, 2021 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors
SES Martin, ZW Tan, HM Itkonen… - Journal of the …, 2018 - ACS Publications
Reversible glycosylation of nuclear and cytoplasmic proteins is an important regulatory
mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase …
mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase …
O-GlcNAc as an integrator of signaling pathways
O-GlcNAcylation is an important posttranslational modification governed by a single pair of
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
Interplay between autophagy and the ubiquitin-proteasome system and its role in the pathogenesis of age-related macular degeneration
J Blasiak, E Pawlowska, J Szczepanska… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis
factors, including defective cellular waste management in retinal pigment epithelium (RPE) …
factors, including defective cellular waste management in retinal pigment epithelium (RPE) …
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …
Integration of O-GlcNAc into stress response pathways
KMM Fahie, KN Papanicolaou, NE Zachara - Cells, 2022 - mdpi.com
The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …