It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its
coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B12-dependent methylmalonyl-CoA …

The radical S-adenosylmethionine (rSAM) enzyme SuiB catalyzes the formation of an
unusual carbon–carbon bond between the sidechains of lysine (Lys) and tryptophan (Trp) in …

Covering: up to the end of 2017 C–C bond formations are frequently the key steps in
cofactor and natural product biosynthesis. Historically, C–C bond formations were thought to …

Gut microbiota of centenarians has garnered significant attention in recent years, with most
studies concentrating on the analysis of microbial composition. However, there is still limited …

The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …

Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a
critical role in blood clotting and prevention of osteoporosis. It has become a focus of …

Although microbial genomes harbor an abundance of biosynthetic gene clusters, there
remain substantial technological gaps that impair the direct correlation of newly discovered …

The H-cluster of [FeFe]-hydrogenase consists of a [4Fe–4S] H-subcluster linked by a
cysteinyl bridge to a unique organometallic [2Fe] H-subcluster assigned as the site of …