Prostate cancer remains a leading cause of cancer death, as there are no durable means to
treat advanced disease. Treatment of non-organ-confined prostate cancer hinges on its …

Nuclear receptors (NR) impact a myriad of physiological processes including homeostasis,
reproduction, development, and metabolism. NRs are regulated by post-translational …

Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

Simple Summary Post-translational modification—the biochemical addition of functional
groups or proteins—occurs following protein biosynthesis and contributes to an increase in …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and
second leading cause of cancer-related deaths in US males. Clinically, locally confined …

The androgen receptor (AR) is important in the development of the prostate by regulating
transcription, cellular proliferation, and apoptosis. AR undergoes posttranslational …

Regulation of the androgen receptor (AR) by its cognate ligand is well established, but how
post-translational modification modulates AR activity is only emerging. The AR is subject to …

Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions
worldwide for its anti-tumor efficacy. Celastrol and Triptolide, two active components …

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs)
was discovered over a decade ago, a huge number of cellular proteins have been found to …