Evolution of cytokinin biosynthesis and degradation

I Frébort, M Kowalska, T Hluska… - Journal of …, 2011 - academic.oup.com
Cytokinin hormones are important regulators of development and environmental responses
of plants that execute their action via the molecular machinery of signal perception and …

New insights into the biology of cytokinin degradation

T Werner, I Köllmer, I Bartrina, K Holst… - Plant …, 2006 - thieme-connect.com
A survey of recent results is presented concerning the role of cytokinin degradation in plants,
which is catalyzed by cytokinin oxidase/dehydrogenase (CKX) enzymes. An overview of …

To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes

A Mattevi - Trends in biochemical sciences, 2006 - cell.com
Flavin-dependent enzymes catalyse a wide range of reactions and, thereby, facilitate a
variety of cellular processes. Among the properties that equip flavoenzymes with this …

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

J Neres, F Pojer, E Molteni, LR Chiarelli… - Science translational …, 2012 - science.org
The benzothiazinone BTZ043 is a tuberculosis drug candidate with nanomolar whole-cell
activity. BTZ043 targets the DprE1 catalytic component of the essential enzyme …

Cytokinins–recent news and views of evolutionally old molecules

L Spíchal - Functional Plant Biology, 2012 - CSIRO Publishing
Cytokinins (CKs) are evolutionally old and highly conserved low-mass molecules that have
been identified in almost all known organisms. In plants, they evolved into an important …

ThermoFAD, a Thermofluor®‐adapted flavin ad hoc detection system for protein folding and ligand binding

F Forneris, R Orru, D Bonivento, LR Chiarelli… - The FEBS …, 2009 - Wiley Online Library
In living organisms, genes encoding proteins that contain flavins as a prosthetic group
constitute approximately 2–3% of the total. The fluorescence of flavin cofactors in these …

What's in a covalent bond? On the role and formation of covalently bound flavin cofactors

DPHM Heuts, NS Scrutton, WS McIntire… - The FEBS …, 2009 - Wiley Online Library
Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors
may be bound to the enzyme in a noncovalent or covalent manner. Although most …

Molecular basis for cytokinin biosynthesis

T Kamada-Nobusada, H Sakakibara - Phytochemistry, 2009 - Elsevier
Cytokinins (CKs) are a group of phytohormones that play a crucial role in the regulation of
plant growth and development. Identification of the enzymes and the corresponding genes …

Biochemical Characterization of Cytokinin Oxidases/Dehydrogenases from Arabidopsis thaliana Expressed in Nicotiana tabacum L.

P Galuszka, H Popelková, T Werner… - Journal of Plant Growth …, 2007 - Springer
Transgenic tobacco plants overexpressing single Arabidopsis thaliana cytokinin
dehydrogenase (CKX, EC 1.5. 99.12) genes AtCKX1, AtCKX2, AtCKX3, AtCKX4, AtCKX5 …

CYTOKININ OXIDASE/DEHYDROGENASE3 Maintains Cytokinin Homeostasis during Root and Nodule Development in Lotus japonicus

DE Reid, AB Heckmann, O Novák, S Kelly… - Plant …, 2016 - academic.oup.com
Cytokinins are required for symbiotic nodule development in legumes, and cytokinin
signaling responses occur locally in nodule primordia and in developing nodules. Here, we …