Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Y Zhang, Q Li, Z Huang, B Li, EC Nice, C Huang, L Wei… - Cancers, 2022 - mdpi.com
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Cancer cell metabolic plasticity in migration and metastasis

JA Mosier, SC Schwager, DA Boyajian… - Clinical & experimental …, 2021 - Springer
Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

In what area of biology has a “new” type of cell death been discovered?

X Wang, J Lin, Z Li, M Wang - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Cell death is a fundamental physiological process that occurs in all organisms and is crucial
to each organism's evolution, ability to maintain a stable internal environment, and the …

Endothelial cell glucose metabolism and angiogenesis

W Du, L Ren, MH Hamblin, Y Fan - Biomedicines, 2021 - mdpi.com
Angiogenesis, a process of new blood vessel formation from the pre-existing vascular bed,
is a critical event in various physiological and pathological settings. Over the last few years …

An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors

MK Temre, A Kumar, SM Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

[HTML][HTML] Nano-constructs targeting the primary cellular energy source of cancer cells for modulating tumor progression

K Yadav, D Singh, MR Singh, M Pradhan - OpenNano, 2022 - Elsevier
Cancer cells, like all other cells in the body, require energy to perform basic functions,
develop, and survive. Glucose metabolism (GM) is the primary energy source for cancer …

Glycolysis, The Sweet Appetite of the Tumour Microenvironment

Z Kooshan, L Cárdenas-Piedra, J Clements, J Batra - Cancer Letters, 2024 - Elsevier
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis
and lactate production, even in the presence of sufficient oxygen-a phenomenon known as …

[HTML][HTML] Novel synthetic UV screen compounds inspired in mycosporine-like amino acids (MAAs): Antioxidant capacity, photoprotective properties and toxicity

FL Figueroa, P Castro-Varela, J Vega… - … of Photochemistry and …, 2024 - Elsevier
The combination of environmental stress on the ozone layer, climate change and a greater
sun exposure due to outdoor habits has led to an increase in skin cancer cases and other …

Gestational diabetes mellitus-associated hyperglycemia impairs glucose transporter 3 trafficking in trophoblasts through the downregulation of AMP-activated protein …

L Zhang, X Yu, Y Wu, H Fu, P Xu, Y Zheng… - Frontiers in Cell and …, 2021 - frontiersin.org
AMP-activated protein kinase (AMPK) is an important regulator of glucose metabolism, and
glucose transporter 3 (GLUT3) is an efficient glucose transporter in trophoblasts. Whether …

Glutor, a glucose transporter inhibitor, exerts antineoplastic action on tumor cells of thymic origin: Implication of modulated metabolism, survival, oxidative stress …

MK Temre, S Yadav, Y Goel, SK Pandey… - Frontiers in …, 2022 - frontiersin.org
Neoplastic cells overexpress glucose transporters (GLUT), particularly GLUT1 and GLUT3,
to support altered metabolism. Hence, novel strategies are being explored to effectively …