Numerous lines of evidence suggest that heterocyclic compounds used as analgesic, anti-
inflammatory and anti-migraine agents can be potent regulators of the nitroxidative stress …

Alzheimer′ s disease (AD) is a progressive neurodegenerative disorder characterized by a
gradual decline in memory associated with shrinkage of brain tissue, with localized loss of …

Cyclosporine, the prototype calcineurin inhibitor, transformed immunosuppressant regimens
and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to …

The aim of this study was to optimize the formulation of meloxicam (MEL)-containing human
serum albumin (HSA) nanoparticles for nose-to-brain via a quality by design (QbD) …

Background and Objective: Osteoarthritis (OA) is a disorder of the musculoskeletal system
resulting in worsening of life condition. The research revealed the involvement of oxidative …

Oxidative stress and inflammatory responses have been identified as key elements of
neuronal cell apoptosis. In this study, we investigated the mechanisms by which …

The aim of this study was to compare the in vivo effects on free radical metabolism of 2 non-
steroidal anti-inflammatory drugs (NSAIDs): tenoxicam, an oxicam preferentially …

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human
serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407) …

Background: Celecoxib is a COX-2 nonsteroidal anti-inflammatory drug (NSAID). It is widely
used for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis …

The effect of 21 days of repeated oral administration of levofloxacin and enrofloxacin both
alone and in combination with meloxicam, on the oxidative balance in blood was evaluated …