Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system
N Hanagata - International journal of nanomedicine, 2012 - Taylor & Francis
Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) are
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …
Nanoparticle delivery systems in cancer vaccines
Y Krishnamachari, SM Geary, CD Lemke… - Pharmaceutical …, 2011 - Springer
Therapeutic strategies that involve the manipulation of the host's immune system are gaining
momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively …
momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively …
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
Implanting materials in the body to program host immune cells is a promising alternative to
transplantation of cells manipulated ex vivo to direct an immune response, but doing so …
transplantation of cells manipulated ex vivo to direct an immune response, but doing so …
Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy
H Kim, L Niu, P Larson, TA Kucaba, KA Murphy… - Biomaterials, 2018 - Elsevier
Cytotoxic T lymphocytes (CTLs) play a major role in cancer immunotherapy because of their
ability to directly kill tumor cells and secrete tumor suppressive cytokines. Anticancer …
ability to directly kill tumor cells and secrete tumor suppressive cytokines. Anticancer …
Biodegradable particles as vaccine delivery systems: size matters
Abstract Poly (lactide-co-glycolide)(PLGA) particles have strong potential as antigen delivery
systems. The size of PLGA particles used to vaccinate mice can affect the magnitude of the …
systems. The size of PLGA particles used to vaccinate mice can affect the magnitude of the …
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
HH Jabara, DR McDonald, E Janssen… - Nature …, 2012 - nature.com
The adaptors DOCK8 and MyD88 have been linked to serological memory. Here we report
that DOCK8-deficient patients had impaired antibody responses and considerably fewer …
that DOCK8-deficient patients had impaired antibody responses and considerably fewer …
Recent advances in nanovaccines using biomimetic immunomodulatory materials
The development of vaccines plays a vital role in the effective control of several fatal
diseases. However, effective prophylactic and therapeutic vaccines have yet to be …
diseases. However, effective prophylactic and therapeutic vaccines have yet to be …
[HTML][HTML] Dual stimulation of antigen presenting cells using carbon nanotube-based vaccine delivery system for cancer immunotherapy
Although anti− cancer immuno− based combinatorial therapeutic approaches have shown
promising results, efficient tumour eradication demands further intensification of anti− tumour …
promising results, efficient tumour eradication demands further intensification of anti− tumour …
Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
AL Silva, RA Rosalia, E Varypataki, S Sibuea… - Vaccine, 2015 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) particles have been extensively studied as
biodegradable delivery system to improve the potency and safety of protein-based vaccines …
biodegradable delivery system to improve the potency and safety of protein-based vaccines …
Innovative strategies for co-delivering antigens and CpG oligonucleotides
Y Krishnamachari, AK Salem - Advanced drug delivery reviews, 2009 - Elsevier
Cytosine–phosphorothioate–guanine oligodeoxynucleotides (CpG ODN) is a recent class of
immunostimulatory adjuvants that includes unmethylated CpG dinucleotide sequences …
immunostimulatory adjuvants that includes unmethylated CpG dinucleotide sequences …