Proteins are the molecular machinery of the human body, and their malfunctioning is often
responsible for diseases, making them crucial targets for drug discovery. The three …

Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …

KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks)
channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …

Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …

Personalized medicine is a broad and rapidly advancing field of health care that is informed
by each person's unique clinical, genetic, genomic, and environmental information …

The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …

Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is
associated with prolonged cardiac repolarization time and increased risk of ventricular …

Recently, the concept of quantitative Read-Across Structure-Activity Relationship (q-RASAR)
has been introduced by using various Machine Learning (ML)-derived similarity functions in …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Computer-aided drug design (CADD) often involves virtual screening (VS) of large
compound datasets and the availability of such is vital for drug discovery protocols. We …