Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-
contraction coupling, and ideally this release shuts off completely between heartbeats …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Rationale: The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in
patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …

Heart failure, the leading cause of mortality and morbidity in the developed world, is
characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated …

Aims In atrial fibrillation (AF), abnormalities in Ca2+ release contribute to arrhythmia
generation and contractile dysfunction. We explore whether ryanodine receptor (RyR) …

Background Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+)
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …

Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular
contraction during cardiac excitation-contraction coupling. The fundamental element of …