Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: The potential of therapeutic targeting of the microbiome
The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …
potential to greatly influence metabolism, not only locally but also systemically. There is an …
Neuropathology of incidental Lewy body & prodromal Parkinson's disease
T Koeglsperger, SL Rumpf, P Schließer… - Molecular …, 2023 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic and
environmental factors that results in degeneration of the nigrostriatal dopaminergic pathway …
environmental factors that results in degeneration of the nigrostriatal dopaminergic pathway …
Analysing biological pathways in genome-wide association studies
Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …
Gene–environment-wide association studies: emerging approaches
D Thomas - Nature reviews genetics, 2010 - nature.com
Despite the yield of recent genome-wide association (GWA) studies, the identified variants
explain only a small proportion of the heritability of most complex diseases. This …
explain only a small proportion of the heritability of most complex diseases. This …
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes
Parkinson disease (PD) is a multifactorial neurodegenerative disorder with high incidence in
the elderly, where environmental and genetic factors are involved in etiology. In addition …
the elderly, where environmental and genetic factors are involved in etiology. In addition …
Netrins: versatile extracellular cues with diverse functions
KLW Sun, JP Correia, TE Kennedy - Development, 2011 - journals.biologists.com
Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …
axon migration during neural development. Subsequent findings have demonstrated that …