An overview of current alternative models in the context of ocular surface toxicity
N Bonneau, C Baudouin… - Journal of Applied …, 2022 - Wiley Online Library
The 21st century has seen a steadily increasing social awareness of animal suffering, with
increased attention to ethical considerations. Developing new integrated approaches to …
increased attention to ethical considerations. Developing new integrated approaches to …
Corneal stromal regeneration—keratoconus cell therapy: a review
Background Keratoconus is a corneal ectatic disease caused by stromal thinning leading to
astigmatism and progressive loss of vision. Loss of the keratocytes and excessive …
astigmatism and progressive loss of vision. Loss of the keratocytes and excessive …
Single cell RNA-seq of human cornea organoids identifies cell fates of a developing immature cornea
The cornea is a protective and refractive barrier in the eye crucial for vision. Understanding
the human cornea in health, disease, and cell-based treatments can be greatly advanced …
the human cornea in health, disease, and cell-based treatments can be greatly advanced …
Matrix glycosaminoglycans and proteoglycans in human cornea organoids and similarities with fetal corneal stages
S Ashworth, M Dhanuka, A Khodadadi-Jamayran… - The Ocular Surface, 2025 - Elsevier
Purpose We developed human cornea organoids (HCOs) from induced pluripotent stem
cells (iPSCs) where single-cell RNA-sequence (scRNA-seq) analysis suggested similarity …
cells (iPSCs) where single-cell RNA-sequence (scRNA-seq) analysis suggested similarity …
Advances in Organoid Technology: A Focus on Corneal Limbal Organoids
C Lu, Q Le - Stem Cell Reviews and Reports, 2024 - Springer
Organoid technology provides a versatile platform for simulating organogenesis,
investigating disease pathogenesis, and exploring therapeutic interventions. Among various …
investigating disease pathogenesis, and exploring therapeutic interventions. Among various …
Single cell RNA-seq identifies developing corneal cell fates in the human cornea organoid
The cornea is a protective and refractive barrier in the eye crucial for vision. Understanding
the human cornea in health, disease and cell-based treatments can be greatly advanced …
the human cornea in health, disease and cell-based treatments can be greatly advanced …