Ferroptosis is a form of cell death that has received considerable attention not only as a
means to eradicate defined tumour entities but also because it provides unforeseen insights …

With the increasing use of comprehensive germline genetic testing of children and
adolescents with cancer, it has become evident that pathogenic variants (PVs) in adult-onset …

This is a valid argument. However, the use of an extreme phenotype case–control design
(eg, by using healthy elderly controls to search for cancer associated genes) has been …

Background Emerging evidence suggests that non-coding somatic single nucleotide
variants (SNVs) in cis-regulatory elements (CREs) contribute to cancer by disrupting gene …

Background Neuroblastoma (NB) represents the most frequent and aggressive form of
extracranial solid tumor of infants. Although the overall survival of patients with NB has …

PURPOSE Neuroblastoma survivors have an increased risk of developing subsequent
malignant neoplasms (SMNs), but the risk of subsequent nonmalignant neoplasms (SNMNs) …

Neurodevelopmental cell communication plays a crucial role in neuroblastoma prognosis.
However, determining the impact of these communication pathways on prognosis is …

Abstract Genome-Wide Association Studies (GWAS) have been decisive in elucidating the
genetic predisposition of neuroblastoma (NB). The majority of genetic variants identified in …

The increased availability of genetic technologies has significantly improved the detection of
novel germline variants conferring a predisposition to tumor development in patients with …

Despite advances in the treatment of high-risk neuroblastoma, approximately half of these
patients die from the disease. Targeted therapy based on synthetic lethality associated with …