Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) …

Ceramide, a bioactive sphingolipid, is now at the forefront of cancer research. Classically,
ceramide is thought to induce death, growth inhibition, and senescence in cancer cells …

In this chapter, roles of bioactive sphingolipids in the regulation of cancer pathogenesis and
therapy will be reviewed. Sphingolipids have emerged as bioeffector molecules, which …

Acid ceramidase (N-acylsphingosine deacylase, EC 3.5. 1.23; AC) is the lipid hydrolase
responsible for the degradation of ceramide into sphingosine and free fatty acids within …

The expression of acid ceramidase (AC)–a cysteine amidase that hydrolyses the
proapoptotic lipid ceramide–is abnormally high in several human tumors, which is …

Sphingolipids are a family of lipids that play essential roles both as structural cell membrane
components and in cell signalling. The cellular contents of the various sphingolipid species …

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated
forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial …

Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing
leads to disease progression and cancer relapse. The influence of sphingolipids, such as …