A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action

SN Begum, AS Ray, CH Rahaman - Phytomedicine, 2022 - Elsevier
Abstract Background Eugenol (1-allyl-4-hydroxy-3-methoxybenzene) is an important simple
phenolic compound mainly derived from Syzygium aromaticum and many other plants. It is …

From natural sources to synthetic derivatives: The allyl motif as a powerful tool for fragment-based design in cancer treatment

N Astrain-Redin, C Sanmartin… - Journal of Medicinal …, 2023 - ACS Publications
Since the beginning of history, natural products have been an abundant source of bioactive
molecules for the treatment of different diseases, including cancer. Many allyl derivatives …

Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

A Elfadadny, RF Ragab, R Hamada… - Toxicology and Applied …, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Molecular mechanisms of action of eugenol in cancer: recent trends and advancement

I Padhy, P Paul, T Sharma, S Banerjee, A Mondal - Life, 2022 - mdpi.com
Background: Cancer is, at present, among the leading causes of morbidity globally. Despite
advances in treatment regimens for cancer, patients suffer from poor prognoses. In this …

Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives

MS Nafie, NH Elghazawy, SM Owf, K Arafa… - Chemico-Biological …, 2022 - Elsevier
New semi-synthetic effective and safe anticancer agents isoeugenol derivatives were
synthesized, characterized, and screened for their cytotoxic activity against MCF-7 …

[HTML][HTML] Bioactive compounds and their libraries: an insight into prospective phytotherapeutics approach for oral mucocutaneous cancers

HA Adeola, A Bano, R Vats, A Vashishtha… - Biomedicine & …, 2021 - Elsevier
Oral mucocutaneous cancers (OMCs) are cancers that affect both the oral mucosa and
perioral cutaneous structures. Common OMCs are squamous cell carcinoma (SCC), basal …

Combination of conventional drugs with biocompounds derived from cinnamic acid: a promising option for breast cancer therapy

LEF Meirelles, MVF Souza, LR Carobeli, F Morelli… - Biomedicines, 2023 - mdpi.com
Despite the options available for breast cancer (BC) therapy, several adverse effects and
resistance limit the success of the treatment. Furthermore, the use of a single drug is …

Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways …

SV Raghu, AK Kudva, S Rao, K Prasad, J Mudgal… - Food & Function, 2021 - pubs.rsc.org
Chemobrain or chemofog is one of the important but less investigated side effects, where the
cancer survivors treated with chemotherapy develop long-term cognitive impairments …

Complexity and diversity of FOXP3 isoforms: Novel insights into the regulation of the immune response in metastatic breast cancer

RR Malla, M Adem, A Chakraborty - International Immunopharmacology, 2023 - Elsevier
FOXP3 is a key transcription factor in the regulation of immune responses, and recent
studies have uncovered the complexity and diversity of FOXP3 isoforms in various cancers …

Pharmacodynamic, pharmacokinetic, toxicity, and recent advances in Eugenol's potential benefits against natural and chemical noxious agents: A mechanistic review

N Tavvabi-Kashani, M Hasanpour, VB Rahimi… - Toxicon, 2024 - Elsevier
The active biological phytochemicals, crucial compounds employed in creating hundreds of
medications, are derived from valuable and medicinally significant plants. These …