More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which
mainstream treatments have not changed for decades. To identify additional therapeutic …

Histone modifications, such as the frequently occurring lysine succinylation,, are central to
the regulation of chromatin-based processes. However, the mechanism and functional …

The transition from transcription initiation to elongation is a key regulatory step in gene
expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing …

Radiotherapy is the primary treatment for patients with nasopharyngeal carcinoma (NPC),
and approximately 20% of patients experience treatment failure due to tumour …

The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic
acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the …

Histone posttranslational modifications (PTMs) regulate chromatin structure and dynamics
during various DNA-associated processes. Here, we report that lysine glutarylation (Kglu) …

Recognition of modified histones by “reader” proteins constitutes a key mechanism
regulating diverse chromatin-associated processes important for normal and neoplastic …

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification,
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …