Centrioles are microtubule-derived structures that are essential for the formation of
centrosomes, cilia and flagella. The centrosome is the major microtubule organiser in animal …

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder. It is
characterized by two principal features, microcephaly present at birth and nonprogressive …

We show that female sterile mutations of aurora (aur) are allelic to mutations in the lethal
complementation group ck TM. This lies in a cytogenetic interval, 87A7-A9, that contains …

One of the most notable trends in mammalian evolution is the massive increase in size of the
cerebral cortex, especially in primates. Humans with autosomal recessive primary …

During metaphase, sister chromatids are positioned at the midpoint of the microtubule-
based mitotic spindle in preparation for their segregation. The onset of anaphase triggers …

We show that mutation in polo leads to a variety of abnormal mitoses in Drosophila larval
neuroblasts. These include otherwise normal looking mitotic spindles upon which …

Microcephaly is defined as a reduction in head circumference and this clinical finding infers
that an individual has a significant diminution in brain volume. Microcephaly can be usefully …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

Background: The centrosome is composed of a centriole pair and pericentriolar material
(PCM). By marking the site of PCM assembly, the centrioles define the number of …

The size of human brain tripled over a period of∼ 2 million years (MY) that ended 0.2–0.4
MY ago. This evolutionary expansion is believed to be important to the emergence of human …